Ativan and Xanax may both be benzodiazepine drugs, but there are key differences between each medication and what they may be used to treat.

Ativan vs Xanax

Benzodiazepines, also known as benzos, are a class of sedative drugs used to treat anxiety, panic disorders, muscle spasms and seizures. Currently, Ativan (lorazepam) and Xanax (alprazolam) are two of the most commonly prescribed benzodiazepines. There are many similarities between the two medications, including what they are used to treat and how they affect the body. However, there are also some key differences.

The similarities and differences between Ativan and Xanax include:

	Ativan	Xanax
Generic Name	Lorazepam	Alprazolam
Drug Class	Benzodiazepine	Benzodiazepine
Drug Schedule	Schedule IV	Schedule IV
Uses	Anxiety, procedural anxiety, epilepsy	Anxiety disorders
Dosage	0.5 mg to 2 mg every four to six hours as needed (max 10 mg/day)	0.25 mg to 4 mg every four to six hours (max 10 mg/day)
Short-term or Long-term Use	Short-term	Short-term
Side Effects	Sedation, dizziness, weakness, unsteadiness	Drowsiness, lightheadedness
Warnings	High potential for abuse, can affect the liver and kidneys, tolerance may develop quickly, should not be used in older patients	High potential for abuse, can affect the liver and kidneys, tolerance may develop quickly, should not be used in older patients
Drug Interactions	Alcohol and other CNS depressants	Alcohol and other CNS depressants

Similarities Between Ativan and Xanax

Ativan and Xanax both affect a chemical messenger of the brain called gamma-aminobutyric acid (GABA). GABA helps regulate communication between nerve cells in the brain. Benzos enhance GABA’s effects and reduce the activity of nerves in the brain to produce a relaxing effect on the mind and body.

Since Ativan and Xanax have similar effects on the body, they are often prescribed for similar reasons. For example, they may be used as a short-term treatment for anxiety.

Both medications have a number of side effects, including:

• Drowsiness
• Dizziness
• Dry mouth
• Headache
• Blurred vision
• Nausea
• Changes in appetite
• Constipation
• Low blood pressure
• Muscle weakness
• Problems with memory
• Insomnia
• Loss of balance or coordination

If you are taking Ativan or Xanax, you should not drive or operate heavy machinery because many of these side effects can impair alertness.

Important Warning

Benzos like Ativan and Xanax can be addictive if used in excess or over an extended period of time. Ending use abruptly can cause dangerous withdrawal symptoms, including:

• Nausea
• Vomiting
• Tremors
• Seizures
• Heart problems

Due to the potential for abuse and addiction, these drugs are only prescribed for short-term use and given in the lowest doses necessary.

Ativan vs Xanax: Differences

The most significant difference between Xanax and Ativan is the way each medication is processed by the body. Ativan has a slightly longer active time than Xanax, as Ativan’s effects peak within two to six hours after consumption. Once Xanax is consumed, its effects peak within one to two hours.

The half-life of each substance, or the amount of time required for a drug’s concentration to be reduced by half in the body, also varies significantly. The average half-life of Ativan is 10–20 hours, while the average half-life of Xanax typically falls between 12 and 15 hours.

What They Treat

Both Ativan and Xanax are used to treat anxiety, but these medicines can also be used for other reasons. For example, Ativan is also approved for use as a pre-surgery sedative.

Both drugs have several off-label uses for other conditions or problems, including:

• Irritability
• Mania from bipolar disorder
• Seizures
• Vomiting from chemotherapy
• Alcohol withdrawal symptoms

Ativan vs Xanax: Side Effects

Although Ativan and Xanax have many of the same side effects, some side effects of Xanax differ from those of Ativan. These include:

• Confusion
• Fatigue
• Sweating

Ativan vs Xanax: Which is Better?

Each medication is extremely similar in medical situations. The primary difference is how long they work in the body, so each has different situations where they may work best. For example, Xanax is used more often for panic attacks because it has a very quick onset and wears off quickly. Ativan is often used in situations that require several hours of sedation, such as when someone is agitated or about to begin a medical procedure.

If you or someone you love is struggling with benzodiazepines like Ativan or Xanax, Xanax Online Center can help. We offer a full continuum of care that can address benzo addiction as well as co-occurring mental health disorders like anxiety. Contact us today to learn more about treatment programs that can work well for your situation.

Which one works quicker?

Xanax is usually more quickly absorbed than Ativan with peak concentrations occurring within 1-2 hours following administration, compared to 2 hours for Ativan.^1,2 Effects of Xanax last on average 4 to 6 hours although there are wide variations between individuals (see below). Effects of Ativan last approximately 8 hours, although may persist for longer in some people.^1,2

How much Xanax equals 1mg of Ativan?

Benzodiazepine equivalency tables state that 0.5mg of alprazolam (Xanax) is approximately equivalent to 1mg lorazepam (Ativan).³ However, people of Asian descent metabolize Xanax differently to people of other races, and certain disease states such as alcoholism, liver and kidney disease, obesity and even old age can affect how Xanax behaves in the body; so benzodiazepine equivalency tables should be used as a guide only as they do not reflect individual variation.^1,2,3 Both Ativan and Xanax should only be used short-term.^1,2,3

How do Ativan and Xanax work?

Both Ativan and Xanax, like all benzodiazepines, enhance the actions of a neurotransmitter in the brain called GABA (gamma-aminobutyric acid).^1,2 This neurotransmitter can reduce the activity of nerve cells, so enhancing it has a calming effect which can improve symptoms of anxiety, reduce muscle tension, stop seizures, and induce sleep. Benzodiazepines are also known for their amnesic effect – or ability to disrupt short-term memory – and this makes them useful before surgery. Because of structural differences, some benzodiazepines are more likely than others to make you sleepy, relieve anxiety, stop seizures, relax muscles, or make you forget.^1,2,3 Ativan and Xanax are both FDA approved for anxiety-relief, and are less likely than some other benzodiazepines (such as diazepam or temazepam) to induce sleep. Sedative effects of lorazepam that did occur were of slower onset but lasted longer than alprazolam in one trial.⁴ Lorazepam may also be used in the treatment of seizures.¹

Which drug is more effective for anxiety?

Trials that directly compared Ativan and Xanax for the treatment of anxiety have reported no significant differences in their effect, and few differences in their side effects, although mental confusion may be less with Xanax.^5,6

Which drug is more addictive?

Both Ativan and Xanax should only be used short-term due to risk of addiction and dependence. Generally speaking, benzodiazepines with a shorter half life (such as Ativan and Xanax) are harder to stop than those with a longer half life (such as diazepam). Both Ativan and Xanax readily enter brain tissue which reinforces drug taking and is generally associated with more severe withdrawal symptoms. Therefore, Ativan and Xanax are both at high risk of abuse. Research directly comparing Ativan with Xanax is not available; however, many experts have particularly advised that Xanax be used with caution as it has been associated with particularly severe withdrawal symptoms.

WHAT DRUGS INTERACT WITH ATIVAN?

Ativan produces increased central nervous system (CNS) depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants,and anesthetics

The use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.

WHAT DRUGS INTERACT WITH XANAX?

Do not take Xanax if you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in Xanax. See the end of this Medication Guide for a complete list of ingredients in Xanax. you are taking antifungal medicines including ketoconazole and itraconazole.

HOW SHOULD ATIVAN BE TAKEN?

Ativan (lorazepam) is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available.

The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

For anxiety, most patients require an initial dose of 2 to 3 mg/day given two or three times a day.

For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given, usually at bedtime.

For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated.

The dosage of Ativan (lorazepam) should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.

HOW SHOULD XANAX BE TAKEN?

Take Xanax exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Xanax to take and when to take it. If you take too much Xanax, call your healthcare provider or go to the nearest hospital emergency room right away.

Xanax is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma and death.

Xanax can make you sleepy or dizzy, and can slow your thinking and motor skills.

Do not drive, operate heavy machinery, or do other dangerous activities until you know how Xanax affects you.

Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking Xanax without first talking to your healthcare provider. When taken with alcohol or drugs that cause sleepiness or dizziness, Xanax may make your sleepiness or dizziness much worse.

Do not take more Xanax than prescribed.

The Mechanism of Action of Xanax and Alcohol

According to the two-volume set The Oxford Handbook of Substance Abuse and Substance Use Disorders, Xanax facilitates the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in an indirect manner and increases the concentration of dopamine in the central nervous system. This combination results in both the sedative/tranquilizing effects of Xanax as well as the mild euphoria that is associated with its use.

Alcohol is a substance that produces varied different effects depending on the dosage. At low doses, many individuals feel stimulated and invigorated, whereas at more moderate to higher doses, individuals find themselves becoming more sedated or relaxed. The primary effects of alcohol are to affect the concentration of the inhibitory neurotransmitter GABA, increasing the effects of the inhibitory neurotransmitter glycine (which is prevalent in the spinal cord and brain stem and decreasing actions of neural transmitters that are excitatory. Alcohol use also affects dopamine levels in the brain mostly through its influence on a particular serotonin receptor. Thus, the mechanism of action for both Xanax and other benzodiazepines and alcohol share numerous similarities.

Even though most sources report that abuse of benzodiazepines like Xanax more commonly occurs in conjunction with abuse of other drugs, polysubstance abuse figures can be unreliable.  According to the Substance Abuse and Mental Health Services Administration (SAMHSA), the yearly rate of emergency room visits for co-occurring benzodiazepine and alcohol use remained stable at around 20,000 cases per year until 2008 when it jumped to around 27,000 cases nationally and remained at that level until SAMHSA stopped collecting information for the Drug Abuse Warning Network (DAWN) surveys.

Effects Associated with Mixing Xanax and Alcohol

When taken within its therapeutic dosage range, Xanax is generally considered to be safe. When individuals take small doses of both Xanax and alcohol, the potential for severe interactions is minimized compared to the potential effects that could occur with higher doses. At lower doses, both substances are easily metabolized, but when individuals begin using higher doses of one or both substances, this puts significant strain on the system. Having one beer and one Xanax is obviously not as problematic as drinking a 12-pack of beer and taking six or seven Xanax. Obviously, larger amounts of either or both substances during same time period lead to greater potential effects and interactions between the two drugs.

Individuals who use Xanax and alcohol together will experience the effects of both substances, but technically, the specific effects and reactions that occur as a result of using these drugs together will depend on whether one consumes more alcohol relative to Xanax or more Xanax relative to alcohol. Using larger quantities of alcohol compared to Xanax will result in significantly more lethargy and sedation; however, because mixing the drugs will result in synergistic effects, using significantly more Xanax and alcohol will also produce levels of sedation and lethargy, but individuals may also experience more euphoria as opposed to overt depression or irritability.

Thus, individuals using both drugs will experience heightened effects of anxiety reduction, sedation, lethargy, decreased motor reflexes, etc. However, individuals who consume significantly more alcohol relative to Xanax are far more likely to become unconscious or pass out quickly, although certainly use of both drugs in any amount can lead to unconsciousness and even comatose states.

Moreover, because the liver makes metabolizing alcohol a priority over almost all other substances, individuals who drink significant amounts of alcohol while taking Xanax will eliminate Xanax from their system at a slower pace than if they just take Xanax alone. This can result in a dangerous buildup of Xanax in the system.

Numerous sources have documented the dangers of potentially mixing benzodiazepines like Xanax and alcohol. According to the book series Neuropathology of Drug Addiction and Substance Abuse, these dangers include:

• Relaxation and euphoria: The use of both drugs will immediately result in increased feelings of relaxation, a marked reduction in anxiety or perceived stress, and mild feelings of euphoria. These effects most often occur at smaller doses. As individuals take larger doses of one or both drugs, sedation typically takes over.
• Fatigue, lethargy, and lightheadedness: Individuals taking both Xanax and alcohol will most likely experience some level of lightheadedness. This may be a result of decreased blood pressure (see below). Lightheadedness can be particularly dangerous when an individual is rising from a sitting or lying position, and the more Xanax and/or alcohol one consumes, the more significant the situation is likely to be. In addition, lightheadedness may continue after one has recovered from their substance use.Fatigue and lethargy are very common symptoms following the use of Xanax and alcohol together. Fatigue and lethargy can be expressed both physically and mentally with individuals moving more slowly, feeling more tired, lacking energy, and experiencing problems with concentration, thinking, and even memory.
• Aggression and irritability: Several early studies have found that individuals who use alcohol and benzodiazepines like Xanax together are far more prone to become aggressive, irritable, and angry than individuals who use either substance alone. Even though these drugs produce increased feelings of relaxation and less vulnerability to stress, they also inhibit an individual’s ability to self-monitor their feelings and behaviors, and interfere with their ability to inhibit impulsive actions. As individuals take these drugs in greater quantities, these effects become even more salient. Individuals who have a history of issues with impulse control, anger, outbursts of anger, etc., will often demonstrate this effect rather quickly. Even individuals who do not have a history of violence or anger management issues may become more irritable and aggressive, and demonstrate outbursts of anger under the influence of these drugs.
• Cognitive issues: Individuals taking alcohol and Xanax in combination will inevitably suffer some cognitive issues. These are dose-dependent; typically, at lower doses, an individual will feel rather “fuzzy” or “spaced out”, and they may move or think more slowly than normal. At higher doses, these effects can become far more significant.

Due to the synergistic properties of both drugs resulting in decreased flow of blood to the brain and increases in inhibitory neurotransmitters, individuals will often begin to experience significant issues with critical thinking, problem-solving, reasoning, self-control, planning, and judgment. In addition, as individuals begin to use more of one or both substances, they may become confused and will not be able to make sense of their environment.

Because of the increased action of inhibitory neurotransmitters, individuals will often experience difficulty forming new memories while under the influence of these drugs. Taking these drugs in sufficient quantities increases the risk that one will suffer a blackout, where one is still responding to the environment (albeit in an impaired way) but later has no memory of the events that occurred.

Again, this is the result of the synergistic effects of these drugs inhibiting the functioning of neurotransmitters that are excitatory and that function in many different types of cognitive abilities, including the ability to form new memories. Chronic use of these drugs may produce lasting changes in the brain that inhibit these functions.

• Cardiovascular and respiratory effects: The general action of these drugs taken singularly is to suppress the functioning of the autonomic nervous system. When used in combination, their synergistic effects can enhance these actions. Obviously, one of the major dangers in using any central nervous system depressant is the drug’s ability to shut down functioning in areas of the brain stem that control automatic life-sustaining functions, such as heart rate, respiration, etc. Even individuals who do not use these drugs at dangerous levels but continue to use them in combination may suffer numerous respiratory and cardiac issues due to chronically slowing these functions and making one system more vulnerable to infections and other disorders. Taking too much of one or both of these drugs can shut down these areas in the brain, and an individual can stop breathing, which can be fatal. Even chronically decreased oxygen flow (hypoxia) to areas of the brain and other organs as a result of chronic use of central nervous system depressant drugs can result in significant brain or other organ damage.
• Increased potential for unconsciousness or comatose states: Continuing to engage in the use of these drugs in combination increases an individual’s potential to become unconscious or even comatose.
• Increased potential for liver and kidney damage: Chronically mixing these drugs burdens the liver to metabolize them and rid them from the system. Similar burdens are placed on the kidneys as the system attempts to eliminate the substances. Individuals who chronically abuse multiple drugs are at increased risk to develop liver and kidney damage and disorders compared individuals who use these drugs singularly.
• Increased risk for overdose: Using central nervous system depressants in combination with one another increases the potential to overdose on either or both drugs. Individuals may lose track of how many Xanax they take, how much alcohol they drink, or be unable to judge how much more of either drug they can handle. In addition, because the drugs are metabolized at different rates and alcohol is typically metabolized before any other substance, individuals may still have dangerously high levels of Xanax in their system even after several hours. This can lead to a potentially dangerous situation if the person starts taking drugs again.
• Increased potential for peculiar effects: When individuals mix drugs, they become more prone to developing unusual side effects or even allergic reactions to one or both drugs.
• Increased potential for psychosis or neurological effects: Mixing Xanax and alcohol increases the potential that one will experience hallucinations and/or delusions or even seizures compared to when using either drug alone.
• Increased potential for the development of physical dependence: Both Xanax and alcohol can produce physical dependence in individuals who use them for a significant length of time. Using both drugs chronically can increase this potential and the potential for very complicated polysubstance abuse issues.
• The development of a substance use disorder: There is a direct relationship between using more substances together chronically and the development of a substance use disorder. Individuals who chronically misuse Xanax and alcohol are increasing their risk to develop a formal substance use disorder to one or both drugs.

Snorting Xanax is extremely dangerous as it can increase the risk of addiction, overdose, nasal cavity damage, and other unwanted side effects. If you or someone you love is addicted to Xanax, please contact Carolina Center for Recovery today to learn about our substance abuse treatment options.

Xanax is the brand name for alprazolam, a benzodiazepine drug that is available via prescription only. Alprazolam is used to treat anxiety, insomnia, stress disorders, and panic disorders. It is the most widely prescribed and abused benzodiazepine in the United States.[1]

Like other benzodiazepines, Xanax slows down the central nervous system (CNS), producing a calming, sedating effect on the body. Snorting Xanax is a popular method of abuse by teens and young adults because they believe insufflation (snorting) will produce stronger effects with a rapid onset.

Why Do People Snort Xanax?

Most of the time, when people start abusing prescription drugs they do so by taking a higher dose than prescribed or taking a dose more frequently than directed. Increasing your dose of a drug like Xanax will build your tolerance to the substance, meaning you’ll have to continue increasing your dose to feel the desired effects.

One way people attempt to overcome a growing tolerance is to change the method of drug administration. Instead of swallowing a pill, people may crush and sniff or snort the powder from the pill. The idea behind snorting is that the mucous membranes in the nose are very thin, so the drug can reach the bloodstream faster, and the user can feel the effects quicker and stronger than they would if they had simply swallowed it.

Although people believe snorting Xanax will produce a faster and stronger high, studies have shown that the difference in onset of effects and peak effects is insignificant when comparing insufflation vs. swallowing. This is because Xanax is fat-soluble and doesn’t dissolve well in water, so the nasal membrane has a difficult time absorbing it. There are more risks associated with Xanax insufflation than there are benefits.

The Effects of Snorting Xanax

Snorting Xanax produces nearly the same short-term effects as it does when taken orally. People tend to feel the effects within 15-20 minutes after insufflation and the effects can last for a couple of hours depending on the dose they took and their tolerance level.

Common Xanax side effects include:

• Relaxation
• Drowsiness
• Disorientation
• Poor concentration
• Delayed reaction time
• Headaches
• Impaired memory
• Nausea
• Constipation
• Sleepiness
• Forgetfulness
• Slurred speech
• Glossy eyes

Because insufflation can deliver higher concentrations of Xanax to the bloodstream quickly, people who snort the drug may also be at an increased risk of agitation, extreme confusion, tachycardia, and respiratory depression.

Risks and Dangers of Xanax Insufflation

Snorting Xanax can be more dangerous than taking it orally because it can damage the airway, lead to infection, increase the risk of addiction, or result in an overdose. Unfortunately, the pleasurable effects Xanax abuse produces may lead people to continue abusing the drug until they are severely addicted.

Damage to the Nose and Upper Respiratory Tract

Xanax pills contain more than just alprazolam–they also contain corn starch and other fillers that can irritate the inside of the nose if it is inhaled. This irritation can eventually lead to nasal cavity infection, lung infection, or respiratory blockage.

Other ways Xanax sufflation can harm your nose and upper respiratory system include:

• Nosebleeds
• Smell loss
• Thinning nasal tissue
• Holes in the nasal cavity
• Whistling noise coming from the nose
• Throat irritation
• Lung damage

Xanax Addiction

When people snort Xanax, they often inhale multiple pills or do so very frequently. This increases the risk of dependence and addiction.

Signs of Xanax addiction include:

• Regular drowsiness, confusion, or cognitive problems
• Memory loss
• Frequently exhibiting a drunk-like state (slurred speech, loss of balance, poor coordination, etc)
• Running out of the prescription early and needing more refills than usual
• Stealing Xanax from friends or family or buying it on the street
• “Doctor shopping,” or visiting multiple doctors trying to get more refills
• Lying about drug abuse
• Changes in behavior, eating, sleeping, and mood
• Making multiple failed attempts to stop using Xanax
• Having withdrawal symptoms when you stop taking Xanax
• Spending excess time and money on Xanax
• Isolating from loved ones

Drug Overdose

Snorting causes the body to develop tolerance rapidly, encouraging users to increase their regular dose. Using large doses of Xanax, especially when snorting it, can thereby increase the risk of overdose.

Another risk involves fake Xanax pills or “pressies.” These pills look like Xanax, but are manufactured illicitly in clandestine laboratories. Counterfeit Xanax pills may contain stronger, more lethal drugs such as fentanyl, which can substantially increase the overdose risk.

Signs of drug overdose include:[1]

• Confusion
• Slurred speech
• Tremors
• Slowed heartbeat
• Loss of consciousness
• Blu-ish colored lips and fingernails
• Unresponsiveness
• Chest pain
• Convulsions
• Coma
• Death

What Does Snorting Xanax Do?

Xanax is available in tablets, concentrated solution (liquid), orally disintegrating tablets, and extended-release tablets for oral administration. However, crushing Xanax pills and snorting them is believed to produce faster effects than oral administration.

Snorting Xanax comes with many adverse effects. When one snorts Xanax, it is possible to develop a substance abuse disorder. This is because the tendency of drug misuse is partly determined by its speed of onset.

Xanax Abuse Signs and Symptoms

It is important to know the signs and symptoms of Xanax abuse to know when help is needed for you or your loved one. Some or all of these symptoms of addiction will appear in anyone who abuses Xanax, whether they snort it, take it orally, or combine it with other drugs like alcohol. Alcohol, or other substances, can exacerbate some of these symptoms as well. It’s important to not mix Xanax with any other substances, as it can result in many dangerous outcomes.

Why Do People Crush Up and Snort Xanax?

Some users prefer crushing Xanax pills and inhaling them via the nose since based on the claim that they experience the effects of the drug much sooner than ingesting them.

Snorting is the preferred way for many users to abuse substances including Xanax. However, both the immediate and long-term effects might cause serious harm. 6

Can You Get High From Snorting Xanax?

Snorting Xanax can cause an intense high.  When a person snorts Xanax, the crushed pills are absorbed into the bloodstream and brain through the mucous membrane in the nasal passages to produce the high. Getting that euphoric feeling encourages people to keep using the drugs, which can lead to a substance abuse disorder.

Does Snorting Xanax Make It More Effective? 

Snorting various medicines results in a stronger and quicker effect. Xanax, however, is fat-soluble and doesn’t dissolve well in water, meaning that nasal membranes have a difficult time absorbing it. Therefore, snorting Xanax is not more effective than when it’s taken orally.

Dangers of Snorting Xanax

When Xanax is snorted, it works rapidly in the brain to produce calming effects. This pleasurable effect of Xanax may lead people to abuse the drug, and even lead to a Xanax overdose which can be fatal.

There’s a misconception that snorting Xanax is the best way to get the Xanax high, compared with injecting or smoking Xanax. While the risk of getting HIV from sharing needles is reduced, snorting Xanax can cause serious health complications. Some of the dangers of snorting Xanax include:

Nasal Tissue Damage

Damage to the nasal membrane is one of the adverse effects of snorting Xanax. As the blood flow to these membranes decreases over time, they get thinner and finally might disappear entirely.

Holes in the Nasal Cavity

When the nasal membrane is damaged, the piece of cartilage that divides the nasal passageways (septum) will be exposed, which can lead to a hole appearing between the nostrils. Subsequently, the nose may collapse when the holes grow until the septum is no longer there. 

Harmful Substances In the Airway

The nasal membrane protects harmful substances from entering the airway. When the membrane is destroyed from snorting Xanax, it loses this protection.

Irritation of the Throat

Snorting Xanax can irritate the throat when the drug drips into the throat and vocal cords. This can also cause a scratchy voice.

Lung Damage

When all the protective tissues in the nasal cavity are damaged, harmful substances can get into the lungs through the nose and cause damage.

Disease

Paraphernalia like straws, dollar bills, rolls of paper, or hollow pens may be used for snorting Xanax. Sharing these items entails sharing bodily fluid, which may be contaminated with viruses like HIV or Hepatitis C.

Find Help for Xanax Abuse and Addiction Today

In recent years, Xanax abuse has skyrocketed in the United States. 1.7% (or about 4.8 million people) reported misusing benzodiazepines like Xanax in 2020.[3] If you or someone you love may be addicted to Xanax, know that there is help available.

Carolina Center for Recovery is a state-licensed and CARF (commission on accreditation of rehabilitation facilities) accredited substance abuse treatment facility. We are a dual-diagnosis facility with a primary focus on substance abuse. We offer individualized, extended-term treatment in an intimate setting located in Charlotte, NC. Contact us today to learn how we can help you begin your recovery journey.

References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846112/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326558/
3. https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse

Xanax (Alprazolam):

Xanax (Alprazolam) is an oral medicine belonging to the benzodiazepine family of drugs that is majorly used to treat anxiety disorders, specifically panic attacks. Panic attacks under schizophrenia are as well usually treated by oral injection of Xanax. If you want to buy Xanax for sale without prescription, considering ordering it from our website.

Xanax & Schizophrenia:

Usage of Xanax to treat schizophrenic patients has been medically approved. This medication is used to treat panic anxiety attacks in schizophrenic patients. 

Schizophrenia is a psychotic condition where the patient fails to draw a line between reality and imagination. Often, the affected individuals perceive reality differently, changing the overall dynamics of their actions, emotions, and behavior.

Xanax treatment is majorly used to calm the nerves for patients with schizophrenia which remains to be one of the most chronic mental disorders due to the fact that it has no potential cure. 

Taking Xanax helps a person suffering from this illness, from whom the world poses a puzzle where he/she is drawn towards a constant sense of fright and anxiety. Moreover, the symptoms are not limited to just that and extend through an array of self-created scenarios due to the effect of hallucinations and delusions. 

Physicians have found it hard to decipher the root cause of this mental state. In fact, there are no official medical causes for Schizophrenia therefore finding an accurate treatment for it is at present not found. What doctors though have tried is to treat the symptoms caused by it by putting the patient on benzos and other psychotropic drugs. By taking Xanax and other benzodiazepines panic attacks caused due to hallucination can be largely subdued and taken control of in a patient. 

As stress is believed to be a trigger point in the process, numerous treatment procedures to control restlessness in patients have been formulated along with the administered use of Xanax. Calming down the brain cells through anti-anxiety drugs like Xanax remains to be a popular resort among doctors.

Xanax (Alprazolam) Important Information:

Xanax (alprazolam) helps people who suffer from the symptoms of stress, anxiety, panic disorders, depression, and other such disorders. Most people who take Xanax for the disorder present testimonials as to how the sedative calms their minds in various instances.

Though Xanax does not treat or cure this mental condition, it proves to be an effective aid in influencing GABA receptors of the brain. Patients who often hallucinate experience extreme restlessness and agitation, where the use of Xanax helps increase the effects of certain neurotransmitters to evoke a soothing response.

Most importantly, patients are able to control their thoughts to an extent, reducing the intensity of symptoms.

Xanax Side Effects:

Doctors also advise Xanax users to be wary of the side effects as any medication used without moderation can pose serious threats. This medication might become habit-forming when it is taken in abnormal quantities without supervision.

It is also important to consult your doctor and know the interactions of Xanax with other medications, that one may be taking for other ailments. Note that taking Xanax with other medications can lead to interaction and cause serious complications.

Xanax Habituation

Xanax (Alprazolam) is a habit-forming drug and is commonly abused. The drug works by modulating Gamma-aminobutyric receptors. In long term, the receptors become receptive and adaptive of alprazolam thereby requiring larger doses to create a subduing effect. Thus leading to addiction and abuse. The addiction to the drug grows with time and hence, it is necessary to track dosage levels periodically, restricting the usage to prescribed doses. A physician’s advice and guidance will prove to be helpful in the competent use of the anti-anxiety pill.

With an incurable condition such as schizophrenia, using Xanax to help with symptoms therefore controlling the panic attacks due to hallucination. Xanax works wonderfully as a relief medication for such patients who can keep their minds relaxed temporarily and derive its fullest potential by consuming it at admissible levels.

Consider Ordering Xanax on our website at affordable prices.

What is 1p-LSD?

1P-LSD stands for 1-propionyl-lysergic acid diethylamide. It’s a derivative of LSD — which essentially means it’s a modified version of the classic LSD-25 that Albert Hofmann discovered in 1943.

This molecule is differentiated from LSD by a propionyl group attached to the nitrogen molecule in the indole portion of LSD. The central indole molecule of LSD is the characterizing element of the molecule that’s shared with all other tryptamine-based psychedelics (such as DMT or psilocybin).

1P-LSD itself is only mildly psychedelic. It has a 67-fold less binding affinity for the 5-HT1A receptors, 13-fold less activity at the 5-HT2A receptors, and a 3.5-fold increase at h5-HT2C receptors than LSD-25 [1].

However, 1P-LSD is a prodrug for LSD, which means it’s converted to LSD by the liver, which then goes on to produce psychoactive effects [2]. The bioavailability of LSD from 1P-LSD is nearly 100%.

History and Culture

1P-LSD first appeared on the online research chemical market in January 2015.[1] Although it was likely discovered in an academic setting, it is unknown who first synthesized 1P-LSD, as the substance does not appear in any academic literature pre-dating its arrival on the research chemical market.[3]

Interestingly, the future usage of 1-alkylated lysergamide derivatives as a means to bypass controlled substance laws banning LSD as a precursor was foreseen in a DEA report from 1988:

“ …a reduction in hallucinogenic activity may become acceptable to the U.S. clandestine chemist when he notes that lysergic acid amide is listed as a Schedule III substance in the CFR; therefore, structurally similar substances of this compound are exempted from the CsA amendment.
A lucid argument can then be made that lysergic acid N,N-dimethylamide is derived from lysergic acid amide rather than LSD. Carrying this theme to the next logical step one would then assume that the 1-alkyl and 1-acyl derivatives of the N,N-dimethyl isomer would also not be controlled by the CsA amendment.

Chemistry

1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH₃CH₂CO- bound to an amino group.

1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.

Pharmacology

Based on its structural similarity to LSD, 1P-LSD likely acts as a partial agonist at the 5-HT2A receptor. The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain.

1P-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, there is currently no experimental data to support these claims.

It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo.[3] Otherwise, it is possible that 1P-LSD possesses intrinsic activity.

Prior to the publishing of the above-cited research, medicinal chemist and psychedelics researcher David E. Nichols reportedly commented on the potential 1P-LSD serotonin receptor binding dynamics in private correspondence:

“ I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don’t know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don’t know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won’t fit into the receptor. ”
— David E. Nichols.[5]
A 2020 study on two human male volunteers found that the levels of 1P-LSD in the serum after administration quickly diminished within the first hour while LSD has been found consistently during the experiment, which further supports the prodrug theory.[6] The study also found that LSD’s bioavailability after oral ingestion of 1P-LSD was close to 100%.

Additionally, it has been theorized that 1P-LSD may act as a prodrug of LSD. This is further concluded via a LC-MS where LSD is detected when 1P-LSD is incubated in human serum. Thus far it remains unclear if 1P-LSD is hydrolyzed to LSD in vivo.

Effects of 1p-LSD

The effects profile of 1P-LSD is not well defined in the scientific literature. It is generally thought to be comparable to that of LSD. A study in 2020 found that intravenous administration of 1P-LSD has a somewhat shorter duration than LSD in humans. 1P-LSD is present for a very short time (4 hours) prior to being completed metabolized to LSD. The 2020 study found that it is not possible to reliably distinguish between the oral uptake of LSD and 1P-LSD until unique metabolites are detected by sensitive analytical methods.

Qualitative effects were similar when comparing intravenous and oral delivery between the two drugs. The slow onset after intravenous application for 1P-LSD appears to be due to the slowed passage of LSD into the central nervous system compared to other serotonergic hallucinogens. Some users in the study reported an absence of “bad drug effects”, but this is likely due to the setting than as a characteristic of 1P-LSD.

Physical Effects

• Stimulation – 1P-LSD is usually regarded as very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocybin which are generally sedating and relaxed.
• Spontaneous bodily sensations – The “body high” of 1P-LSD can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location-specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of 1P-LSD, this sensation often approaches its highest level and can become so overwhelming that people may find themselves debilitated with pleasurable sensations.
  • Physical euphoria – It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as extreme physical discomfort without any apparent reason.
• Tactile enhancement – Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most 1P-LSD experiences. If level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person’s entire body all at once is consistently present.
• Stamina enhancement – This is generally mild in comparison to the stamina enhancement produced by traditional stimulants.
• Appetite suppression
• Bodily control enhancement
• Difficulty urinating
• Excessive yawning – This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
• Nausea – Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly soon after the user has vomited or gradually fades by itself as the peak sets in.
• Increased blood pressure^{[citation needed]}
• Increased heart rate^{[citation needed]}
• Increased perspiration
• Muscle contractions
• Muscle spasms
• Pupil dilation
• Increased salivation
• Vasoconstriction – Vasoconstriction may lead to users feeling cold, especially in the extremities.
• Seizure – The likelihood is largely extrapolated from the seizures that have been reported from the use of LSD. It is thought to mainly be a risk in those who are genetically predisposed to them, particularly while accompanied by physically taxing conditions such as states of dehydration, fatigue, undernourishment or overheating.

Cognitive Effects

• Analysis enhancement – This effect is consistent in its manifestation and introspection dominant.
• Anxiety & Paranoia – This effect is not as common at low to moderate doses and is less likely to occur when the basic rules of set and setting are taken into account. It should be noted that this inconsistently induced effect is seemingly more likely to manifest when used with cannabis. This combination should be used with extreme caution if one is not experienced with psychedelics, meaning that the user should adequately pace themselves with a fraction of their usual amount. It is commonly reported that psychedelics can to a certain extent counteract some of the perceived mental cloudiness or intoxicating effects of THC causing the user to in turn use more cannabis than is needed which can often lead to an overwhelmingly anxious headspace or a “bad trip”.
• Catharsis
• Conceptual thinking
• Creativity enhancement
• Emotion enhancement
• Novelty enhancement
• Personal bias suppression
• Personal meaning enhancement
• Focus enhancement – This effect is experienced exclusively on low or threshold dosages and feels less forced than it does with stimulants.
• Immersion enhancement
• Suggestibility enhancement
• Cognitive euphoria – This component is, generally speaking less consistent and pronounced than it is with substances like psilocybin and MDMA. The mental euphoria experienced on LSD is usually simply due to an enhancement of the user’s current psychological and emotional state coupled with its more regularly occurring effect, physical euphoria.
• Delusion
• Déjà vu
• Increased libido
• Increased music appreciation
• Increased sense of humor
  • Laughter fits – This can manifest prominently during a 1P-LSD experience, particularly during the come up phase, often resulting in bouts of uncontrollable giggles and laughter that can form a feedback loop if around others who are also under the influence.
• Memory suppression
  • Ego death
• Thought acceleration
• Thought disorganization
• Thought loops
• Time distortion
• Wakefulness

Overdose

1P-LSD has no known toxic dose. However, higher doses increase the risk of adverse psychological reactions. These reactions include anxiety, delusions, panic attacks and, more rarely, seizures. Medical attention is usually not needed except in the case of severe psychotic episodes or the ingestion of fake acid (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics can help to relieve the acute negative cognitive effects of 1P-LSD.

Dependence and abuse potential

Although no formal studies have been conducted, it is assumed that like LSD itself, 1P-LSD is non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer LSD — an animal model predictive of abuse liability — indicating that it does not have the necessary pharmacology to either initiate or maintain dependence.^[10] Likewise, there is virtually no withdrawal syndrome when chronic use of LSD is stopped.^{[citation needed]} It is assumed that 1P-LSD shares these properties with LSD.

Tolerance to the effects of 1P-LSD is built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). 1P-LSD produces cross-tolerance with all psychedelics, meaning that after the use of 1P-LSD they will have a reduced effect.

Xanax is a highly addictive benzodiazepine medication that is commonly prescribed to treat anxiety disorders. Many people become addicted to Xanax after being prescribed it, sometimes inadvertently. Others use it recreationally due to its effects of promoting feelings of relaxation and well-being.

However, despite being an effective treatment for anxiety in the short term, Xanax actually causes cognitive damage and causes other health issues with long-term use. Recognizing the signs of Xanax addiction can people identify if they are abusing Xanax, allowing them to seek out treatment as soon as possible to minimize the damage drug addiction can have on their lives.

1. Developing a Tolerance to Xanax

An early sign of Xanax addiction is developing something called tolerance. Tolerance to drugs occurs with prolonged and regular use of a substance. This means that as a person continues to use a drug, even if it is as prescribed, their body gets used to having it in the system. As the body becomes accustomed to having Xanax, the desirable effects diminish and more drugs are needed to achieve the same effect.[2]

People who are prescribed Xanax and struggling with addiction may find themselves taking their medication more frequently than what is prescribed. Recreational Xanax users will notice they are needing to buy Xanax more often as their tolerance increases.

2. Having Cravings for Xanax

Cravings for Xanax are another phenomenon that occurs with substance use disorder. Individuals struggling with Xanax addiction may start the day with every intention of not using drugs that day. However, as the day goes on, they begin to have extremely strong urges to take Xanax.[1]

This is known as cravings. Drug cravings are one of the reasons why Xanax is so addictive. These cravings make it very difficult for a person to stop using Xanax, even if they want to stop.

3. Using Xanax is Negatively Impacting Your Relationships

A side effect of long-term Xanax abuse is changes affecting one’s mental and cognitive state.[1] This results in people acting differently than how they normally would when using Xanax. These personality changes are often very noticeable to friends and family members.

People who are addicted to Xanax find themselves basing their entire day around getting and using the drug. They may become both physically and emotionally unavailable to family and friends. In instances where loved ones approach the person about their problem, the person may become defensive and angry at the people trying to help them.

The behaviors that accompany Xanax addiction severely damage relationships. People struggling with Xanax addiction will find themselves distancing themselves from others to avoid criticism. Others will distance themselves from the person who is addicted to Xanax to avoid being hurt emotionally by seeing a loved one destroy their life.

4. Engaging in Risky Behaviors to Get Xanax

Individuals suffering from addiction will resort to extreme measures in order to obtain their drug of choice. People who are prescribed Xanax and become addicted may engage in “doctor shopping.” This occurs when a person’s physician is no longer willing to prescribe the amounts of Xanax that they want. As a result, individuals may visit multiple doctors with the intention of obtaining multiple different prescriptions.

When doctor shopping doesn’t work, people often turn to buying Xanax on the streets from drug dealers, putting themselves in dangerous situations. If they do not have enough money for Xanax, they may steal from strangers or even loved ones in order to get the money to buy it.

Xanax also lowers a person’s inhibitions and results in them engaging in other risky behaviors such as having sex with strangers, smoking cigarettes, or getting in a car with a driver who is also on drugs.[3]

5. Experiencing Xanax Withdrawal Symptoms

A clear-cut sign of Xanax addiction is experiencing withdrawal symptoms when attempting to stop taking the drug. Symptoms of Xanax withdrawal include:

• Restlessness
• Anxiety
• Mood Changes
• Headaches
• Nausea and vomiting
• Tremors
• Insomnia [1,2]

Xanax withdrawal occurs because the body is so used to having the drug that it needs a period of time to adjust to not having that substance anymore. Xanax withdrawal symptoms are extremely uncomfortable and usually require a period of detox. During detox, the body gets rid of the remaining Xanax and becomes used to functioning without it.[2]

Getting Help For Xanax Addiction

If you believe you are struggling with Xanax addiction, it is important to get help as soon as possible. Getting sober from Xanax is extremely difficult and requires outside help in order for someone to be successful. This includes Xanax detox as well as an inpatient drug rehabilitation program.

At Carolina Recovery Centers, we are here to help you on the difficult journey of recovery. Our highly trained staff works with you closely to address all of your concerns. They will come up with a specialized treatment plan to ensure long-term success in quitting Xanax. Contact us today to get started.

References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846112/
2. https://pubmed.ncbi.nlm.nih.gov/7841856/
3. https://modlab.yale.edu/sites/default/files/files/JournalOfAdoleHealth.pdf

Lion’s mane (Hericium erinaceus) is a type of medicinal mushroom. Long used in traditional Chinese medicine, lion’s mane is widely available in fresh, dried, and supplement form. Scientific research shows that lion’s mane contains a number of health-promoting substances, including antioxidants and beta-glucan

Health Benefits of Lion’s Mane Mushroom

Proponents claim that lion’s mane can help with a variety of health problems, including:

• Alzheimer’s disease
• Anxiety
• Depression
• High cholesterol
• Inflammation
• Parkinson’s disease
• Ulcers

In addition, lion’s mane is said to strengthen the immune system, stimulate digestion, and protect against cancer.

So far, research on the specific health effects of lion’s mane is fairly limited. However, findings from animal-based research, test-tube studies, and small clinical trials indicate that lion’s mane may offer certain health benefits, including support for neuronal health.² Here’s a look at some key study findings.

Brain Function

Lion’s mane may benefit older adults with mild cognitive impairment, according to a small study published in Phytotherapy Research in 2009. For the study, researchers assigned 30 older adults with mild cognitive impairment to take either lion’s mane extract or a placebo every day for 16 weeks. In cognitive tests given at weeks eight, 12, and 16 of the study, members of the lion’s mane group showed significantly greater improvements compared to members of the placebo group.³

In a more recent study (published in Biomedical Research in 2011), scientists examined the effects of lion’s mane on brain function in mice. Results revealed that lion’s mane helped protect against memory problems caused by the buildup of amyloid beta (a substance that forms the brain plaques associated with Alzheimer’s disease).⁴ Studies have also shown a possible neuro-protective effect against ischemic stroke.⁵

The National Center for Complementary and Integrative Health (NCCIH) cautions that while some small preliminary studies on the impact of natural supplements on cognitive function have shown modest effects, “direct evidence is lacking.” Claims made to the contrary are not supported by evidence.

Depression and Anxiety

Research to date suggests that Lion’s mane may help alleviate depression and anxiety. For example, a 2020 review of the literature called Lion’s mane “a potential alternative medicine for the treatment of depression.”⁷

Likewise, a 2021 research review detailed several studies that showed significant anti-anxiety effects. Lion’s mane appears to offer “neuroprotective functions, cytotoxicity, anticarcinogenic, antidiabetic, antimicrobial, and herbicidal activities,” as well.⁸

Cancer

Preliminary research suggests that lion’s mane shows promise in protection against cancer. For example, in a 2011 study published in Food & Function, tests on human cells revealed that lion’s mane may help knock out leukemia cells.⁹

In addition, a 2011 study published in the Journal of Agricultural and Food Chemistry found that lion’s mane extract helped reduce the size of cancerous colon tumors in mice.¹⁰ The study’s findings suggest that lion’s mane may help fight off colon cancer, in part by increasing activity in certain cells involved in the immune response. Another study found that the extract might help reduce the spread of colon cancer cells to the lungs.¹¹ However, it’s too soon to tell whether lion’s mane can help prevent or reduce cancer in humans.

Diabetes

Studies in animals support the use of lion’s mane mushrooms in managing diabetes.¹²¹³ The mushrooms may improve metabolic function by helping to regulate glucose and insulin levels.

Possible Side Effects of Lion’s Mane

Little is known about the safety of long-term use and side effects of lion’s mane supplements.⁵ However, there’s some concern that lion’s mane may aggravate symptoms in people with allergies and asthma. Therefore, it’s important to consult your physician prior to using lion’s mane or any other supplement, especially if you have a history of allergies, asthma, and/or any other medical condition.

Studies on the potential benefits of lion’s mane in humans have shown promise, but research so far has been limited mostly to animals. Always consult your healthcare provider before ingesting lion’s mane or any other supplement.

How to Take Lion’s Mane

Lion’s mane hasn’t been studied enough to establish standard dosages and preparation.¹⁴ General guidelines follow, but always heed your physician’s specific advice regarding medicines and supplements.

Dosage

Lion’s mane is commonly consumed in many Asian countries for medicinal and culinary purposes, but there are no consistent formulations or dosage recommendations. Follow the instructions on your package of lion’s mane closely.

Lion’s Mane Precautions and Interactions

Avoid using lion’s mane mushroom products if you’re pregnant. Not enough research has been done to determine if any dosage is safe during pregnancy.

If you take diabetes medications, be aware that Lion’s mane mushroom can lower your blood glucose levels too much. Keep a close eye on your readings.

Likewise, taking lion’s mane along with anticoagulant/antiplatelet drugs can cause blood clotting difficulties that can result in bleeding or bruising.¹⁵

Some people are allergic to lion’s mane. Seek medical help immediately if you notice throat swelling, breathing trouble, or other signs and symptoms after taking lion’s mane.

What to Look For When Buying Lion’s Mane

Watch out for products claiming proven health benefits in humans; the majority of research has been limited to animal studies.² Some lion’s mane supplements have been marketed with unsupported claims, such as the promotion of weight loss, brain health, and the prevention of heart disease.

For example, in 2019, the Food and Drug Administration (FDA) sent a warning letter to Pure Nootropics, LLC, for making unsubstantiated claims about a variety of their products, including for their lion’s mane powder. The company was marketing the supplement as “great for brain injury recovery” and to “reduce symptoms of anxiety and depression.” Since then, the company has removed these specific claims from their marketing but continue to claim that the product “supports overall cognitive health.”¹⁶

Where to Buy Lion’s Mane Mushroom

Many big-box and specialty online and brick-and-mortar stores sell fresh, dried, and/or powdered Lion’s mane, as well as capsules, teas, and various forms of blends featuring the fungi. In nature, they tend to grow in logs, decaying wood, and tree wounds.

You can buy lion’s mane mushroom from our website because it is FDA approved.

Other Questions About Lion’s Mane

Due to a lack of supporting research, it’s too soon to recommend lion’s mane for any specific health condition.² If you’re considering the use of lion’s mane for a chronic condition, make sure to consult your physician before starting your supplement regimen. Self-treating a chronic condition with lion’s mane and avoiding or delaying standard care may have serious consequences.

If you are experiencing anxiety symptoms, you are certainly not alone—40 million Americans, or 18% of the population, have anxiety. Buspirone (also known by the brand name of BuSpar) and Xanax (alprazolam) are two FDA-approved anti-anxiety drugs that are popular treatment options for generalized anxiety disorder. Although buspirone and Xanax are both anxiolytics (drugs used in the treatment of anxiety), they have notable differences, which we will outline below.

What are the main differences between buspirone and Xanax?

Buspirone is an anti-anxiety medication and is not related to Xanax chemically. Xanax is known as a benzodiazepine. Buspirone is no longer available in its brand-name form of BuSpar—it is only available in generic. Xanax is available in both brand and generic. Buspirone is available in tablet form, while Xanax is available in an immediate-release and extended-release tablet as well as an oral concentrate.

Buspirone (Buspirone coupons | Buspirone details) is in a drug category, or class, of its own, and not related to any other medications used for anxiety. The way buspirone works is not completely understood. We do know that it is different from benzodiazepines like Xanax. Studies have shown that buspirone works on serotonin and dopamine receptors.

Xanax (Xanax coupons | Xanax details) is part of a large class of medications known as benzodiazepines. Benzodiazepines work by increasing activity at receptors for a neurotransmitter called gamma-aminobutyric acid (GABA). This all takes place in the CNS (central nervous system). Benzodiazepines produce a relaxing, calming effect and can even help promote sleep when taken at bedtime. Xanax is a controlled substance and is classified as a Schedule IV drug.

Main differences between buspirone vs Xanax
	Buspirone	Xanax
Drug class	Anti-anxiety medication	Benzodiazepine
Brand/generic status	Generic	Brand and generic
What is the generic name? What is the brand name?	Brand: BuSpar (no longer available as brand)	Generic: alprazolam
What form(s) does the drug come in?	Tablet	Tablet (immediate-release) Extended-release tablet Oral concentrate
What is the standard dosage?	Initial: 7.5 mg twice daily but may slowly increase if needed Average dose is a total of 20 to 30 mg daily in divided doses (example: 15 mg twice daily for a total daily dose of 30 mg)	Usual range: 0.25 mg to 0.5 mg taken 3 times daily; dosage varies
How long is the typical treatment?	Short-term or long-term; consult a doctor	Short-term; some patients use longer under doctor supervision
Who typically uses the medication?	Adults Children 6 years and older (off-label)	Adults Children 7 years and older (off-label)

Conditions treated by buspirone and Xanax

Buspirone and Xanax are most commonly used in the management of anxiety disorders and can help in the short-term relief of symptoms of anxiety, whether or not anxiety is associated with depressive symptoms. Xanax is also used to treat panic disorder, or panic attacks, with or without agoraphobia (fear of crowded places, or fear of leaving the home). Both drugs also are used off-label for a variety of conditions, outlined below.

Condition	Buspirone	Xanax
Management of anxiety disorders	Yes	Yes
Short-term relief of the symptoms of anxiety	Yes	Yes
Short-term relief of anxiety associated with depressive symptoms	Yes	Yes
Treatment of panic disorder, with or without agoraphobia	Off-label	Yes
Rapid tranquilization of the agitated patient	No	Off-label
Alcohol withdrawal delirium/alcohol withdrawal syndrome	Off-label	Off-label
Insomnia	No	Off-label
Bruxism (teeth grinding)	Off-label	Off-label
Chemotherapy-associated anticipatory nausea and vomiting	No	Off-label
Delirium	No	Off-label
Depression	Off-label	Off-label
Essential tremor	No	Off-label
Tardive dyskinesia (repetitive, involuntary movements, often caused by long-term use of antipsychotic medications)	Off-label	Off-label
Post-traumatic stress disorder	Off-label	Off-label
Tinnitus (ringing in the ears)	No	Off-label
Premenstrual syndrome	Off-label	Off-label

Is buspirone or Xanax more effective?

In a study comparing buspirone and Xanax, both drugs were found to be equally effective in treating symptoms of anxiety, and buspirone was found to have less side effects and fewer withdrawal symptoms than Xanax.

Another study looked at buspirone and Xanax, as well as Valium (diazepam), and the effect on daytime sleepiness. The study found buspirone to cause the least drowsiness of the three drugs. By day 7, the differences between the drugs in terms of daytime sleepiness was not significant, but the patients who took alprazolam or diazepam had slower reaction times on a visual reaction timed-performance test. The authors concluded that although the drugs are similarly effective, buspirone may be better in patients where daytime alertness is critical.

The most effective medication for you should only be determined by your doctor, who can look at your medical condition(s) and history, as well as other medications you take.

Common side effects of buspirone vs Xanax

The most common adverse effects of buspirone are dizziness, headache, and weakness. Patients may also experience nausea, nervousness, lightheadedness, and/or excitement.

The most common side effects of Xanax are sedation, dizziness, and weakness. Other side effects that may occur include lightheadedness, memory problems, confusion, dry mouth, disorientation, euphoria, seizures, vertigo, vision changes, slurred speech, sexual problems, headache, coma, respiratory depression (slowed breathing, not getting enough oxygen), and/or GI (gastrointestinal) symptoms such as upset stomach, nausea, constipation, or diarrhea.

Other side effects may occur. Consult your healthcare professional for a full list of side effects.

	Buspirone	Xanax
Side Effect	Applicable?	Frequency	Applicable?	Frequency
Sedation	Yes	4% (same as placebo)	Yes	41-77%
Headache	Yes	6%	Yes	12.9% (but less than placebo)
Dizziness	Yes	12%	Yes	1.8-30%
Weakness	Yes	2%	Yes	6-7%

Source: DailyMed (buspirone), DailyMed (Xanax)

Drug interactions of buspirone and Xanax

MAOIs (monoamine oxidase inhibitors) should not be used within 14 days of buspirone, because the combination could cause serotonin syndrome or increased blood pressure.

Buspirone and Xanax are both processed, or metabolized, by an enzyme called cytochrome-P 450 3A4 (CYP 3A4). Certain drugs inhibit CYP3A4, preventing buspirone or Xanax from being metabolized, and leading to a buildup of buspirone or Xanax (and more side effects). These include diltiazem, erythromycin, and several others. It is important to note that grapefruit juice can inhibit the metabolism of buspirone or Xanax.

On the other hand, certain drugs are CYP3A4 inducers and speed up the metabolism of buspirone or Xanax (and as a result, buspirone or Xanax would not be as effective). These drugs include carbamazepine, phenytoin, rifampin, and barbiturates such as phenobarbital.

Buspirone or Xanax should not be taken with opioid painkillers, due to increased risk of sedation, respiratory depression, and overdose, possibly even leading to death. If no other combination of medicine is possible, the patient should receive both drugs at the lowest possible dose and for the shortest duration of time, and be closely monitored.

Buspirone or Xanax also should not be taken with other CNS depressants, including alcohol, antipsychotics, antidepressants (including SSRIs like Prozac), sedating antihistamines, and anticonvulsants. Depending on the combination, there could be an increased risk for serotonin syndrome, CNS depression (slowing of brain activity), and psychomotor impairment (slowed reaction, for example, when driving).

Other drug interactions may occur. Consult your healthcare provider for medical advice.

Drug	Drug Class	Buspirone	Xanax
Phenelzine Rasagiline Selegiline Tranylcypromine	MAO inhibitors	Yes	No
Diltiazem Erythromycin Itraconazole Ketoconazole Nefazodone Ritonavir Verapamil Grapefruit juice	CYP3A4 inhibitors	Yes	Yes
Carbamazepine Phenobarbital Phenytoin Rifampin	CYP3A4 inducers	Yes	Yes
Codeine Fentanyl Oxycodone Morphine Tramadol	Opioids	Yes	Yes
Alcohol	Alcohol	Yes	Yes
Amitriptyline Citalopram Desipramine Desvenlafaxine Duloxetine Escitalopram Fluoxetine Fluvoxamine Imipramine	Antidepressants	Yes	Yes
Baclofen Carisoprodol Cyclobenzaprine Metaxalone	Muscle relaxants	Yes	Yes
Divalproex sodium Gabapentin Lamotrigine Levetiracetam Pregabalin Topiramate	Anticonvulsants	Yes	Yes
Diphenhydramine	Sedating antihistamines	Yes	Yes
Lo Loestrin Fe, etc	Oral contraceptives	No	Yes

Warnings of buspirone vs Xanax

Buspirone

• Buspirone should not be taken within 14 days of a monoamine oxidase inhibitor (MAOI) such as phenelzine, tranylcypromine, rasagiline, or selegiline. The combination can lead to a dangerous increase in blood pressure, or a condition called serotonin syndrome. Serotonin syndrome is a life-threatening condition that can occur when serotonin levels are too high. When it happens, it is usually because of a drug or combination of drugs (such as antidepressants) that has raised the serotonin levels too much. Serotonin syndrome can be mild (tremors, diarrhea) to severe (fever and seizures) and can lead to death if untreated.
• Do not drive or operate machinery until you know how buspirone affects you.
• Patients with liver or kidney problems should not use buspirone.
• Buspirone has been studied in pregnant animals and showed no harm to the fetus, but there are no adequate studies in pregnant women. Therefore, buspirone should only be used in pregnancy if clearly needed and if approved by your OB/GYN.

Xanax

• Xanax comes with a boxed warning, the strongest warning required by the FDA. Xanax (or any benzodiazepine) should not be taken with opioid painkillers because of the risk of extreme sedation, severe respiratory depression, coma, and/or death. If the combination of a benzodiazepine and opioid cannot be avoided, the patient should be prescribed the lowest dose for the shortest period of time and be closely monitored. Patients should not drive or operate machinery until the effects of the medication are known.
• Xanax may cause physical and psychological dependence—the risk increases with higher doses, longer duration of use, or a history of drug/alcohol abuse. Because patients with panic disorder often use higher doses of Xanax, there may be a higher risk of dependence.
• If you take Xanax, take only as prescribed. Do not take additional doses.
• When discontinuing Xanax, ask your doctor for a plan to taper the medication slowly. This will help you avoid withdrawal symptoms, which may include: seizures, agitation, confusion, rapid heartbeat, vertigo, and other symptoms. Patients with seizure disorders are at higher risk for withdrawal symptoms.
• There is a risk of suicide in patients with depression. Patients with depression should be treated with an antidepressant and should be closely monitored.
• Xanax should be used with caution in patients with lung problems such as COPD or sleep apnea.
• Talk to your doctor about adjusting the dose of Xanax if you have liver problems.
• Xanax is on the Beers’ List (drugs that may be inappropriate for use in older adults). Because older adults have increased sensitivity to benzodiazepines, there is an increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes when Xanax is used.
• Xanax should not be used in pregnancy, because it can cause harm to the fetus. If you are already taking buspirone or Xanax and find out that you are pregnant, contact your OB/GYN immediately.

Frequently asked questions about buspirone vs Xanax

What is buspirone?

Buspirone is a drug used for anxiety. It is available in generic form and is usually covered by insurance.

What is Xanax?

Xanax is part of the benzodiazepine category of drugs. It is used for anxiety and panic disorder. It is available in both brand and generic, and as an immediate-release or extended-release tablet. Xanax is usually covered by insurance in the generic form of alprazolam but may be covered at a higher copay in the brand-name form.

Other benzodiazepines you may have heard of include Ativan (lorazepam), Klonopin (clonazepam), and Valium (diazepam). Because Xanax is a controlled substance with the potential for abuse, it is advisable to store it out of the reach of children, preferably locked up, if possible.

Are buspirone and Xanax the same?

While they both treat anxiety, they work differently. The way buspirone works is not quite understood but involves serotonin and dopamine. Xanax (and other drugs in the benzodiazepine class) works on GABA receptors in the brain.

Is buspirone or Xanax better?

In clinical studies, both drugs were shown to be equally effective for anxiety. However, buspirone may cause less daytime drowsiness.

That being said, both drugs are very popular. Because everyone is different, it is best to check with your doctor and he/she can review your current symptoms and medical history as well as other medications you take, to determine if buspirone or Xanax is better for you.

Can I use buspirone or Xanax while pregnant?

Buspirone is a pregnancy category B. Studies in animals showed no harm to the fetus, but there are no adequate studies in pregnant women. Therefore, buspirone should only be used in pregnancy if the benefits outweigh the risks, and under the supervision of your OB/GYN.

Xanax is a pregnancy category D. Taking the drug while pregnant can cause harm to the baby, and should not be used. If you are already taking buspirone or Xanax and find out that you are pregnant, contact your OB/GYN immediately.

Can I use buspirone or Xanax with alcohol?

No. The combination of buspirone or Xanax with alcohol can be very dangerous or even deadly. Together, alcohol plus buspirone or Xanax can lead to CNS depression (slowed brain activity), respiratory depression (slowed breathing and not getting enough oxygen), and even lead to coma and/or death.

How does buspirone make you feel?

After a week or so, when buspirone starts to kick in, you will start to feel less anxious. You may also experience some side effects, such as dizziness, headache, or weakness. If your dose needs to be increased, your doctor will slowly increase the dose so side effects are minimized. If any side effects are particularly bothersome, check in with your healthcare provider.

How long does it take for buspirone to kick in?

Buspirone does not start working immediately. It can take one or two weeks to begin working, and you may not feel the full effect until four to six weeks.

Can buspirone replace Xanax?

Maybe. Buspirone and Xanax work differently, but they both treat anxiety. Patients taking buspirone tend to experience less sedation. Ask your doctor if one of these drugs is right for you.

Does buspirone help you sleep?

Buspirone is not reported to cause sedation. However, if your anxiety is better in general because you are taking buspirone, you may sleep better as a result of feeling less anxious. In clinical studies, 10% of patients experienced drowsiness, but 9% of patients taking a placebo (an inactive pill) also reported feeling drowsy. Also, 3% of patients reported insomnia, but 3% of patients taking placebo also experienced insomnia.

As the name suggests, penis envy mushrooms resemble a human penis. They have a swollen, rounded cap and thick stem. These mushrooms are a particularly potent variety of Psilocybe cubensis, a species of magic mushrooms.

There are several penis envy varieties, including:

• Albino penis envy: a slightly smaller mushroom with a deep blue–tinged cap
• Penis envy uncut: an albino cross with caps that adhere to the stem
• Penis envy number 6: a hybrid that produces more spores
• Trans penis envy: a hybrid with finer stems and a milder effect than other varieties

These mushrooms contain high concentrationsTrusted Source of the psychedelic compound psilocybin. As a result, people report that consuming these mushrooms produces intense visual and euphoric psychedelic experiences.

As these mushrooms take longer to mature and do not produce many spores, they are difficult to find and cultivate. This means they may be more expensive and harder to source than other varieties of magic mushrooms.

Penis Envy Mushroom History

The history of the Penis Envy mushroom is probably one of the most talked about, but often confused, origin stories of all of the varieties of Psilocybe cubensis. For many years, the go-to article for explaining how Penis Envy emerged was published in Vice in 2009, by journalist-turned-psychedelic-scientist Hamilton Morris. However, in a podcast published on Morris’ own Patreon in June 2021, he admits to having been deliberately misled by the infamous mycologist John Allen (aka Mushroom John, of Psilocybe allenii fame), along with much hearsay found on various fungal forums. 

Morris’ close-to-the-truth story from 2009 is a blend of a range of cult figures and folklore from the mushroom community and roughly proceeds as follows: In the early 1970s, Terrence Mckenna found a huge wild patch of Psilocybe cubensis growing deep in the Columbian Amazon. Though magic mushrooms had recently been made illegal, the spores were not (as is the case in most US states today), so Terrence took several spore prints back to his home in Colorado. One of these prints found its way to Steven Pollock, the medical doctor turned psychedelic mushroom enthusiast, who spent several years isolating the mushrooms to produce the Penis Envy variety—before Pollock’s mysterious murder in 1981.

In more fanciful versions of the tale, Pollock was claimed to be found dead with a Penis Envy mushroom clutched in his hand. A single spore print from Pollock’s phallic experiments (labeled only “penis”) found their way to Rich Gee a Washington-based mycologist, who kept the variety alive, but was ultimately impossible for Morris to track down. And so the story ends, with Pollock receiving credit and Rich Gee merely the caretaker of the variety.

Penis envy mushroom effects

While the effects of magic mushrooms vary depending on the person and dose, they typically produce feelings of euphoria, well-being, and increased creativity. Some people also report experiencing visual or auditory hallucinations.

In some cases, magic mushrooms can induce spiritual experiences and heightened states of consciousness.

For certain people, these effects are deeply meaningful and provide a sense of peace and understanding. For others, they are overwhelming or scary.

When someone consumes psychedelic mushrooms, the psilocybin binds to 5-HT2A serotonin receptors on the surface of nerve cells. Serotonin is the “feel good” chemical that helps regulate mood, thinking ability, perception, and sleep.

Therefore, when psilocybin binds to serotonin receptors, it affects how information flows between different brain regions. This results in changes in consciousness and perception.

These changes can be positive or negative depending on the person’s mindset, expectations, and environment.

Penis envy mushroom effects Vs. other psychedelic mushrooms

There are more than 100 speciesTrusted Source of mushrooms of the genus Psilocybe that produce psilocybin. They are found all over the world.

While all these mushrooms share similar psychedelic effects, each variety produces distinctive experiences depending on its potency, chemistry, and concentration of active metabolites.

Experts classify the effects of psilocybin into four categories:

• Perceptual: Visual and auditory hallucinations and changes in the perception of time, space, and body are common effects of psilocybin mushrooms.
• Cognitive: Alterations in thinking and information processing may make people feel creative and insightful or confused and disorientated.
• Emotional: Positive emotions may include feelings of euphoria, well-being, love, and connectedness. Conversely, negative emotions such as fear, anxiety, or paranoia may affect a person’s trip.
• Ego dissolution: This refers to a sense of self-transcendence or self-forgetfulness. It can cause a feeling of oneness with the universe or a loss of the sense of individuality.

A person’s mindset, metabolism, body composition, and tolerance level affect their experience. It can be incredibly varied from person to person.

People also have distinct reactions to different types of mushrooms. Some people find that the effects of Psilocybe cubensis are more visual and euphoric, while others find them more introspective and spiritual.

How to use them safely

If someone chooses to use magic mushrooms, it is important to do so safely. There are a few things to keep in mind:

• Start with a low dose: It is always best to start with a low dose and increase gradually as desired. This allows time to gauge tolerance level, reducing the risk of negative experiences.
• Be in a safe environment: Because magic mushrooms can cause changes in perception, it is important to be in a safe and comfortable environment. If a person is in an unfamiliar setting, they could get lost, hurt, or have a bad trip.
• Avoid mixing with other substances: Mixing magic mushrooms with other drugs, alcohol, or medications can be harmful. Psilocybin can interact with other substances in unpredictable ways and magnify their effects.
• Know the source: When buying magic mushrooms, it is crucial to source them from a reliable supplier. Some mushroom species can look similar but have different or even dangerous effects.
• Have a positive mindset: Magic mushrooms can amplify emotions. Therefore, if someone is feeling anxious or depressed, it could trigger a bad trip.
• Have a “trip sitter”: This person remains sober and can provide calm and reassuring support if someone needs help while taking mushrooms.

Risks and side effects

Taking psilocybin can trigger persistent disturbing changes in perceptions, feelings, and moods. It can also cause temporary hallucinations, visual flashbacks, and short-term changes in thinking and emotion.

As a result, people can develop anxiety and paranoia.

Sometimes, a person can have flashbacks long after the substance’s effects have worn off. Stress, fatigue, or other environmental factors can trigger these flashbacks. Physicians now diagnose this rare condition as hallucinogen-persisting perception disorder.

When taking mushrooms, there is also a risk of mistakenly consuming poisonous varieties. A person should visit an emergency room immediately if they have symptoms of mushroom poisoning, such as:

• muscle spasms
• confusion
• delirium

Legality

Like other psilocybin-containing mushrooms, penis envy mushrooms are not legal in the United States. They are classified as Schedule I substances under the Controlled Substances Act, along with lysergic acid diethylamide (LSD) and cannabis.

The law considers that substances in this category have no currently accepted medical use and a high potential for misuse.

However, some experts argue that the law has not yet caught up with the science. Both animal and human studies indicate that psilocybin mushrooms have low misuse and no physical dependence prospect. Furthermore, research into psychedelics has shown therapeutic potential for these substances.

It is possible that in the future, the legal status of penis envy mushrooms may change as more research is conducted on their safety and effectiveness.

Several U.S. cities have decriminalized psilocybin. In 2019, Denver, Colorado, became the first city to take this historic step. Others have followed suit, including Oakland, California; Washington, D.C.; and Cambridge, Massachusetts.

In 2022, Colorado voted to decriminalize magic mushrooms statewide for people over 21. This will take effect in 2024.

Furthermore, in 2020, Oregon legalized supervised psilocybin-assisted therapy programs in controlled settings. These moves may pave the way for further research into the therapeutic potential of psilocybin and similar psychedelics.